Abstract |
Paraquat poisoning results in damages of multiple organs including liver, kidney and lung, and antioxidants have been proven to have protective effects. As a novel free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), was introduced to clinical use recently, its protective effect was studied on acute toxicity of paraquat in male ddY mice. When paraquat (175 mg/kg) were given orally, the survival rate was only 8% on the 6th day of paraquat ingestion in Control Group mice. Protective effect of MCI-186 was most evident and the survival rate was 42% on the 6th day and 38% on the 14th day of paraquat ingestion, respectively, when mice were treated immediately. A delay of 30 min in treatment resulted in an abrupt reduction of the survival rate. These results suggested that MCI-186 used in acute phase of paraquat intoxication might serve as a clinically available antidote for attenuating paraquat toxicity.
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Authors | Toshiji Saibara, Katsumi Toda, Akihiko Wakatsuki, Yasuhiro Ogawa, Masafumi Ono, Saburo Onishi |
Journal | Toxicology letters
(Toxicol Lett)
Vol. 143
Issue 1
Pg. 51-4
(Jun 05 2003)
ISSN: 0378-4274 [Print] Netherlands |
PMID | 12697380
(Publication Type: Journal Article)
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Chemical References |
- Free Radical Scavengers
- Herbicides
- Paraquat
- Edaravone
- Antipyrine
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Topics |
- Animals
- Antipyrine
(analogs & derivatives, pharmacology)
- Dose-Response Relationship, Drug
- Edaravone
- Free Radical Scavengers
(pharmacology)
- Herbicides
(antagonists & inhibitors, toxicity)
- Male
- Mice
- Paraquat
(antagonists & inhibitors, toxicity)
- Proportional Hazards Models
- Survival
- Time Factors
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