Abstract |
Trichodermamides A (1) and B (2), two modified dipeptides, have been isolated from cultures of the marine-derived fungus Trichoderma virens. The trichodermamides possess a rare cyclic O-alkyl- oxime functionality incorporated into a six-membered ring. The structure of trichodermamide B was established by X-ray diffraction analysis, while the structure assignment of trichodermamide A, and determination of the absolute stereochemistry, was accomplished by spectral and chemical methods. Trichodermamide B displayed significant in vitro cytotoxicity against HCT-116 human colon carcinoma with an IC(50) of 0.32 microg/mL.
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Authors | Eliane Garo, Courtney M Starks, Paul R Jensen, William Fenical, Emil Lobkovsky, Jon Clardy |
Journal | Journal of natural products
(J Nat Prod)
Vol. 66
Issue 3
Pg. 423-6
(Mar 2003)
ISSN: 0163-3864 [Print] United States |
PMID | 12662106
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antineoplastic Agents
- Dipeptides
- trichodermamide A
- trichodermamide B
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Topics |
- Antineoplastic Agents
(chemistry, isolation & purification, pharmacology)
- Colonic Neoplasms
- Crystallography, X-Ray
- Dipeptides
(chemistry, isolation & purification, pharmacology)
- Drug Screening Assays, Antitumor
- Humans
- Inhibitory Concentration 50
- Molecular Structure
- Papua New Guinea
- Stereoisomerism
- Trichoderma
(chemistry)
- Tumor Cells, Cultured
(drug effects)
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