Dopamine D3 receptor gene Ser9Gly variant and schizophrenia: association study and meta-analysis.

Abstract

OBJECTIVE:

To further evaluate the controversial putative association between a Ser9Gly variant in the first exon of the dopamine D3 receptor gene (DRD3) and schizophrenia.

METHODS:

Swedish patients with schizophrenia ( n=156) and control subjects ( n=463) were assessed for the DRD3 Ser9Gly variant. Meta-analyses including previous and the present Swedish case-control results were performed.

RESULTS:

No significant difference between the Swedish patients and controls were found, but there was an association between DRD3 Ser9Gly Ser/Ser and homozygous genotypes and response to anti-psychotic drugs. This finding was supported by an incomplete meta-analysis. In a meta-analysis of all case-control studies comprising 8761 subjects the association between DRD3 Ser9Gly homozygosity and schizophrenia ( =4.96, degree of freedom=1, p <0.05, odds ratio=1.10, 95% confidence interval=1.01-1.20) persisted. However, the previously proposed association between the Ser/Ser genotype and schizophrenia was not significant (chi2 =2.71, degree of freedom=1, p>0.05, odds ratio=1.08, 95% confidence interval=0.99-1.17).

CONCLUSIONS:

Whereas the present Swedish case-control analysis did not yield any evidence for association with the diagnosis, the present meta-analysis suggests that the DRD3 gene confer susceptibility to schizophrenia. Reasons for the discrepancies between prior studies are discussed.

• Authors: Erik G Jönsson, Lena Flyckt, Edgar Burgert, Marc-Antoine Crocq, Kaj Forslund, Marja Mattila-Evenden, Gunnar Rylander, Marie Asberg, Vishwajit L Nimgaonkar, Gunnar Edman, Lars Bjerkenstedt, Frits-Axel Wiesel, Göran C Sedvall
• Journal: Psychiatric genetics (Psychiatr Genet) Vol. 13 Issue 1 Pg. 1-12 (Mar 2003) ISSN: 0955-8829 [Print] England
• PMID: 12605094 (Publication Type: Comparative Study, Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• DRD3 protein, human
• Receptors, Dopamine D2
• Receptors, Dopamine D3
• Serine
• Glycine

Topics

• Amino Acid Substitution
• Case-Control Studies
• Genetic Variation
• Glycine
• Homozygote
• Humans
• Receptors, Dopamine D2 (genetics)
• Receptors, Dopamine D3
• Reference Values
• Schizophrenia (genetics)
• Serine
• Sweden