Abstract | PURPOSE: Administration of anticancer drugs may damage gastrointestinal epithelium, thereby increasing the permeability of the gastrointestinal mucosa. We estimated the usefulness of oral lactulose and mannitol (L/M) test for assessment the extent of mucosal damage following postoperative chemotherapy for human malignant disease. METHODS: The permeability index (PI): the urinary recovery ratio of excreted L to M was measured before and after chemotherapy in 31 patients with gastrointestinal cancers who underwent surgical resection. These findings were compared with data on 12 patients with breast cancer. The effect of chemotherapy was evaluated by the ratio of increase in PI, which was designed as post- chemotherapy value on day 7 divided by pre- chemotherapy value. RESULTS: CONCLUSIONS: Since the oral L/M absorption test is useful for assessing the degree of mucosal damage and measurement of intestinal permeability, this analysis should be recommended to determine the optimum timing and the adequate dosage of the anticancer drug administration.
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Authors | S Inutsuka, F Takesue, M Yasuda, M Honda, S Nagahama, H Kusumoto, T Nozoe, D Korenaga |
Journal | European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
(Eur Surg Res)
2003 Jan-Feb
Vol. 35
Issue 1
Pg. 22-5
ISSN: 0014-312X [Print] Switzerland |
PMID | 12566783
(Publication Type: Journal Article)
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Copyright | Copyright 2003 S. Karger AG, Basel |
Chemical References |
- Antineoplastic Agents, Phytogenic
- Cyclophosphamide
- Cisplatin
- Fluorouracil
- Camptothecin
- Methotrexate
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Topics |
- Antineoplastic Agents, Phytogenic
(therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Breast Neoplasms
(drug therapy, surgery)
- Camptothecin
(therapeutic use)
- Cisplatin
(therapeutic use)
- Colonic Neoplasms
(drug therapy, surgery)
- Combined Modality Therapy
- Cyclophosphamide
(therapeutic use)
- Fluorouracil
(therapeutic use)
- Humans
- Intestinal Mucosa
(metabolism)
- Methotrexate
(therapeutic use)
- Permeability
(drug effects)
- Stomach Neoplasms
(drug therapy, surgery)
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