[Effect of activation of p-MAPK on activating c-fos and c-jun proteins in breast cancer].

Abstract

OBJECTIVE:

This paper was to investigate the relationship between expression of p-MAPK and oncogenesis of breast cancer.

METHODS:

Immunohistochemical technique was used to detect the expression of p-MAPK and c-fos and c-jun proteins in 68 cases of breast cancers, 42 cases of pericarcinomatous tissues and 7 cases of normal breast tissues.

RESULTS:

Positive stainings of p-MAPK, c-fos, and c-jun were localized in cancer cell nuclei. The positive rates of p-MAPK, c-fos, and c-jun were 86.8% (59/68), 82.4% (56/68), and 77.9% (53/68), respectively, which were much higher than that in pericarcinomatous tissues (P < 0.01). Of some cases, p-MAPK positive staining was also found in the nuclei of the fibroblastic and angioendothelial cells of cancer stroma.

CONCLUSION:

Activated or overexpressive MAPK activates the immediately-early oncogenes(c-fos, c-jun), which might play an important role in carcinogenesis of breast cancer and be an early event of oncogenesis of breast cancer.

• Authors: R X Cheng, D Y Feng, H Zheng, Y Tan
• Journal: Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University (Hunan Yi Ke Da Xue Xue Bao) Vol. 26 Issue 1 Pg. 10-2 (Feb 28 2001) ISSN: 1000-5625 [Print] China
• PMID: 12536603 (Publication Type: English Abstract, Journal Article)

Chemical References

• Proto-Oncogene Proteins c-fos
• Proto-Oncogene Proteins c-jun
• Mitogen-Activated Protein Kinases

Topics

• Adult
• Aged
• Breast Neoplasms (metabolism)
• Carcinoma, Ductal, Breast (metabolism)
• Female
• Humans
• Middle Aged
• Mitogen-Activated Protein Kinases (metabolism)
• Phosphorylation
• Proto-Oncogene Proteins c-fos (metabolism)
• Proto-Oncogene Proteins c-jun (metabolism)
• Signal Transduction