Prospective immunogenicity study of multiple intradermal injections of rabies vaccine in an effort to obtain an early immune response without the use of immunoglobulin.

Abstract

The present study sought to determine whether increasing and accelerating rabies vaccine administration would result in earlier protective levels of neutralizing antibody. Results indicated that the 8-site and double-dose Thai Red Cross intradermal regimens produced higher antibody titers by day 14 but not significantly higher titers by days 5 and 7. Administration of rabies immunoglobulin into and around bite wounds on the first day of rabies prophylaxis should remain the optimal postexposure treatment.

• Authors: Pakamatz Khawplod, Henry Wilde, Saovaluk Tepsumethanon, Sukunya Limusanno, Tanpetch Tantawichien, Pranee Chomchey, Ampai Bungjongkasaena Na Ayuthaya, Yongyuth Wangroonsarb
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 35 Issue 12 Pg. 1562-5 (Dec 15 2002) ISSN: 1537-6591 [Electronic] United States
• PMID: 12471579 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies
• Rabies Vaccines

Topics

• Adult
• Antibodies (administration & dosage, immunology)
• Female
• Humans
• Immunity
• Injections, Intradermal
• Male
• Rabies (immunology, prevention & control)
• Rabies Vaccines (administration & dosage, immunology)