Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS: Despite similar urinary oxalate levels compared with group 2 group 3 rats showed fewer tubulointerstitial lesions, consisting of significant lower scores for tubular atrophy, unspecific inflammatory cell infiltrate, ED1 mouse anti-rat monoclonal antibody (Serotec, Ltd., Oxford, United Kingdom) (monocytes/macrophages), crystal deposits, interstitial fibrosis, alpha-smooth muscle actin, collagen type III and tubulointerstitial transforming growth factor-beta1. Moreover, urinary albumin excretion and creatinine clearance were significantly improved in group 3 (p <0.01). Higher total glutathione and lower thiobarbituric acid reactive substances were also observed in this group (p <0.01). Thiobarbituric acid reactive substances were the most important and significant independent variable correlating with interstitial fibrosis (t ratio 4.867, p <0.04). CONCLUSIONS: We believe that the renal- angiotensin system interaction by losartan produces a beneficial effect against renal lesions caused by hyperoxaluria through a number of actions, including a reduction in crystal formation in the tubular fluid, inflammatory reaction control and interaction with oxidative stress. These factors lead concurrently to preserve tubular epithelial cell and renal interstitium integrity. In addition, these results suggest that the principal mechanism of action should be mediated by angiotensin II type 1 receptors.
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Authors | Jorge Eduardo Toblli, León Ferder, Inés Stella, Elena M V De Cavanaugh, Margarita Angerosa, Felipe Inserra |
Journal | The Journal of urology
(J Urol)
Vol. 168
Issue 4 Pt 1
Pg. 1550-5
(Oct 2002)
ISSN: 0022-5347 [Print] United States |
PMID | 12352456
(Publication Type: Journal Article)
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Chemical References |
- Angiotensin Receptor Antagonists
- Receptor, Angiotensin, Type 1
- Losartan
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Topics |
- Angiotensin Receptor Antagonists
- Animals
- Atrophy
- Fibrosis
- Hyperoxaluria
(pathology)
- Kidney Tubules
(drug effects, pathology)
- Losartan
(pharmacology)
- Male
- Nephritis, Interstitial
(pathology)
- Rats
- Rats, Sprague-Dawley
- Receptor, Angiotensin, Type 1
- Renin-Angiotensin System
(drug effects)
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