Studies on the mechanism of the protective and antidotal actions of diazepam in organophosphate poisoning.

Abstract	The effect of diazepam on soman-induced bradycardia and respiratory depression in rabbits has been investigated. Diazepam prevents the bradycardia produced by soman in conscious rabbits. Although atropine will reverse the respiratory depression produced by soman in anesthetized rabbits, diazepam enhances the depression and renders rabbits less susceptible to this action of atropine.
Authors	D D Johnson, W C Wilcox
Journal	European journal of pharmacology (Eur J Pharmacol) Vol. 34 Issue 1 Pg. 127-32 (Nov 1975) ISSN: 0014-2999 [Print] Netherlands
PMID	1234758 (Publication Type: Journal Article)
Chemical References	Antidotes Atropine Soman Diazepam
Topics	Animals Antidotes Atropine (pharmacology) Blood Pressure (drug effects) Depression, Chemical Diazepam (pharmacology, therapeutic use) Drug Interactions Heart Rate (drug effects) Organophosphate Poisoning Rabbits Respiration (drug effects) Soman (pharmacology) Time Factors

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