Synthesis of poly(maleimide-co-2-ethylacrylic acid) and its properties of suppressing metastasis and growth of carcinoma.

Abstract	A series of copolymers is prepared using maleimide and 2-ethylacrylic acid as comonomer. This kind of copolymer shows low toxicity (LD50: 601-798 mg/kg) and significant curative effect on Lewis lung carcinoma and S180.
Authors	Zhongliang Zhu, Lianjun Shi, Junlian Huang
Journal	Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 12 Issue 20 Pg. 2843-6 (Oct 21 2002) ISSN: 0960-894X [Print] England
PMID	12270159 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Acrylates Antineoplastic Agents Indicators and Reagents Polymers poly(maleimide-co-2-ethylacrylic acid)
Topics	Acrylates (chemical synthesis, pharmacology) Animals Antineoplastic Agents (chemical synthesis, pharmacology, toxicity) Carcinoma, Lewis Lung (drug therapy, pathology) Dose-Response Relationship, Drug Drug Design Indicators and Reagents Lethal Dose 50 Mice Neoplasm Metastasis (drug therapy, pathology) Neoplasm Transplantation Polymers (chemical synthesis, pharmacology) Sarcoma 180 (drug therapy, pathology) Structure-Activity Relationship

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