Abstract | OBJECTIVES: BACKGROUND: METHODS: Chronic heart failure was induced in Wistar rats by chronic ligation of the left anterior descending coronary artery. Left ventricular (LV) function and ex vivo vascular contractility and relaxation were measured 10 weeks after the surgery. Nitrotyrosine (NT) formation and PARP activation were detected by immunohistochemistry. RESULTS: Chronic heart failure induced increased NT formation and PARP activation in the myocardium and intramural vasculature, depressed LV performance, and impaired vascular relaxation of aortic rings. PJ34 significantly decreased myocardial PARP activation but not NT formation, and improved both cardiac dysfunction and vascular relaxation. CONCLUSIONS:
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Authors | Pál Pacher, Lucas Liaudet, Jon g Mabley, Katalin Komjáti, Csaba Szabó |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 40
Issue 5
Pg. 1006-16
(Sep 04 2002)
ISSN: 0735-1097 [Print] United States |
PMID | 12225730
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Enzyme Inhibitors
- N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride
- Phenanthrenes
- Poly(ADP-ribose) Polymerase Inhibitors
- 3-nitrotyrosine
- Tyrosine
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Topics |
- Animals
- Enzyme Activation
- Enzyme Inhibitors
(pharmacology)
- Heart Failure
(drug therapy, physiopathology)
- Immunohistochemistry
- Male
- Phenanthrenes
(pharmacology)
- Poly(ADP-ribose) Polymerase Inhibitors
- Rats
- Rats, Wistar
- Tyrosine
(analogs & derivatives, biosynthesis)
- Vasomotor System
(drug effects)
- Ventricular Function, Left
(drug effects)
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