We examined the expression of
survivin using immunohistochemistry in 102 cases of
laryngeal squamous cell carcinoma (LSCC). Overall, 65.7% (67 out of 102) of
tumors were positive for
survivin expression and significantly associated with
tumor site, poor differentiation,
tumor size,
lymph node metastasis and advanced stage. Kaplan-Meier analysis showed that
survivin expression was significantly associated with shorter disease-free and overall survival respectively. When
survivin expression and clinical stage were combined, patients with both
survivin-positive and advanced stage (III, IV) revealed poorer disease-free and overall survival when compared with the other cases (p = 0.0002 and p = 0.0002, respectively). Additionally, in early stage (I, II) cases,
survivin expression also showed a significant prognostic trend for disease-free and overall survival (p = 0.0727 and p = 0.0701, respectively). By the multivariate analysis,
tumor size,
lymph node metastasis and
survivin expression were independent prognostic factors both in disease-free and overall survival. These findings indicate that
survivin expression is associated with unfavorable clinicopathological parameters and represents an independent marker for prognosis of LSCC.