Abstract | AIM: METHODS: Four groups of subjects were studied (all males); Group 1 comprised of non-diabetic subjects without CAD (n=50). Non-diabetic subjects with CAD formed group 2 (n=50); group 3 comprised of type 2 diabetic patients without CAD (n=50) and group 4 consisted of type 2 diabetic patients with CAD (n=50). CAD was diagnosed based on coronary angiographic evidence of severe double or triple vessel disease. RESULTS: Both diabetic and non-diabetic patients with CAD had significantly higher levels of tPA, PAI-1 and fibrinogen compared to non-diabetic without CAD (p < 0.05). Patients with CAD were distributed more in the upper tertiles of these risk factors compared to those without CAD. A strong association between tPA and PAI-1 was noted in the Pearson's correlation analysis (p < 0.001). Univariate regression analysis showed tPA (Odds ratio--1.12, p = 0.03), PAI-1 (Odds ratio--1.03, p = 0.008), fibrinogen (Odds ratio--1.01, p < 0.0001), serum cholesterol (Odds ratio--1.008, p = 0.04) and hypertension (Odds ratio--3.7, p = 0.0001) to be associated with CAD. Multiple logistic regression analysis revealed hypertension (Odds ratio--4.6, 95% confidence interval--2.113-9.950, p = 0.0001) and fibrinogen (Odds ratio--1.012, 95% confidence interval--1.007-1.018, p = 0.0001) as risk factors for CAD. CONCLUSION: Our study suggests that prothrombogenic risk factors particularly fibrinogen may be associated with CAD in South Indians.
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Authors | R Deepa, K Velmurugan, G Saravanan, V Dwarakanath, S Agarwal, V Mohan |
Journal | The Journal of the Association of Physicians of India
(J Assoc Physicians India)
Vol. 50
Pg. 901-6
(Jul 2002)
ISSN: 0004-5772 [Print] India |
PMID | 12126344
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Plasminogen Activator Inhibitor 1
- Fibrinogen
- Tissue Plasminogen Activator
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Topics |
- Analysis of Variance
- Coronary Disease
(blood, etiology)
- Developing Countries
- Fibrinogen
(metabolism)
- Humans
- India
- Male
- Middle Aged
- Plasminogen Activator Inhibitor 1
(blood)
- Risk Factors
- Tissue Plasminogen Activator
(blood)
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