Effects of oral N-acetylcysteine on plasma homocysteine and whole blood glutathione levels in healthy, non-pregnant women.

Abstract

Oral N-acetylcysteine supplementation in nine young healthy females induced a quick and highly significant decrease in plasma homocysteine levels and an increase in whole blood concentration of the antioxidant glutathione. N-acetylcysteine impresses as an efficient drug in lowering homocysteine concentration and might be beneficial for individuals with hyperhomocysteinemia who are at increased risk of cardiovascular disease.

• Authors: Eva Maria Roes, Maarten T M Raijmakers, Wilbert H M Peters, Eric A P Steegers
• Journal: Clinical chemistry and laboratory medicine (Clin Chem Lab Med) Vol. 40 Issue 5 Pg. 496-8 (May 2002) ISSN: 1434-6621 [Print] Germany
• PMID: 12113295 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Homocysteine
• Glutathione
• Acetylcysteine

Topics

• Acetylcysteine (administration & dosage, pharmacology)
• Administration, Oral
• Adult
• Antioxidants
• Dietary Supplements
• Female
• Glutathione (blood, drug effects)
• Homocysteine (blood, drug effects)
• Humans
• Hyperhomocysteinemia (drug therapy)