[A case of miliary tuberculosis complicated by acute respiratory failure after bronchofiberscopy].

Abstract

A 79-year-old man presented with persistent nonproductive cough and high fever. The chest radiograph showed bilateral miliary shadows. We performed bronchoalveolar lavage and transbronchial lung biopsy to assist diagnosis. Severe dyspnea developed after the bronchofiberscopy, when the chest radiograph revealed bilateral ground-glass shadows and the oxygen saturation in the room air fell to 60%. It was suspected that the patient had acute respiratory distress syndrome, so that methylprednisolone was given intravenously at a dose of 250 mg daily for 3 days, which resulted in a reduction in ground glass shadows and an improvement in oxygen saturation. We diagnosed miliary tuberculosis because the transbronchial lung biopsy specimen showed caseous granuloma and the PCR test for Mycobacterium tuberculosis in the bronchoalveolar lavage fluid was positive. The patient was cured with antituberculosis chemotherapy.

• Authors: Toshihiko Hashizume, Kanemitsu Kawada
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 40 Issue 4 Pg. 304-6 (Apr 2002) ISSN: 1343-3490 [Print] Japan
• PMID: 12096499 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Methylprednisolone

Topics

• Aged
• Anti-Inflammatory Agents (administration & dosage)
• Biopsy
• Bronchoscopy (adverse effects)
• Humans
• Lung (pathology)
• Male
• Methylprednisolone (administration & dosage)
• Respiratory Insufficiency (drug therapy, etiology)
• Tuberculosis, Miliary (complications)