Rabeprazole in nonerosive gastroesophageal reflux disease: a randomized placebo-controlled trial.

Abstract

OBJECTIVES:

Clinical results to date suggest that antisecretory therapy may be less effective in providing symptom relief for patients with nonerosive gastroesophageal reflux disease (GERD) than for patients with erosive disease. This study was carried out to assess the efficacy and rapidity of once-daily rabeprazole (10 mg or 20 mg) in relieving symptoms in endoscopically negative patients with moderately severe GERD symptoms and to evaluate the safety of these doses over 4 wk.

METHODS:

This placebo-controlled, double blind study enrolled 203 men and women with moderately severe symptoms of GERD. After a 2-wk, single-blind placebo run-in phase, patients were randomized to receive 10 mg or 20 mg of rabeprazole or placebo once daily for 4 wk.

RESULTS:

Rabeprazole rapidly and effectively relieved heartburn, with significant improvements on day 1 of dosing. It also improved most other GERD-related symptoms, including regurgitation, belching, bloating, early satiety, and nausea. Both rabeprazole doses were significantly superior to the placebo with respect to time to the first 24-h heartburn-free interval (2.5 and 4.5 days for 10 mg and 20 mg of rabeprazole, respectively, vs 21.5 days for the placebo) and first daytime or nighttime heartburn-free interval (1.5-3 days for rabeprazole groups vs 12.5-15 days for the placebo), as well as to percentage of time patients were heartburn-free and free of antacid use. Both rabeprazole doses were well tolerated.

CONCLUSIONS:

Based on these findings and prior studies, rabeprazole reliably relieves GI symptoms equally well in both nonerosive GERD and erosive GERD.

• Authors: Philip Miner Jr, William Orr, Joseph Filippone, Leonard Jokubaitis, Sheldon Sloan
• Journal: The American journal of gastroenterology (Am J Gastroenterol) Vol. 97 Issue 6 Pg. 1332-9 (Jun 2002) ISSN: 0002-9270 [Print] United States
• PMID: 12094846 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Benzimidazoles
• Enzyme Inhibitors
• Rabeprazole
• Omeprazole

Topics

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Adult
• Benzimidazoles (administration & dosage, adverse effects, therapeutic use)
• Dose-Response Relationship, Drug
• Double-Blind Method
• Drug Administration Schedule
• Enzyme Inhibitors (administration & dosage, adverse effects, therapeutic use)
• Female
• Gastroesophageal Reflux (drug therapy)
• Humans
• Male
• Middle Aged
• Omeprazole (analogs & derivatives)
• Rabeprazole
• Safety
• Single-Blind Method
• Treatment Outcome