Abstract | BACKGROUND AND AIMS: METHODS AND PATIENTS: Concentrations of glutamine, glutamate, and alanine were measured pre- and postoperatively in the terminal ileal mucosa, pouch mucosa, skeletal muscle and venous blood of patients undergoing IPAA for UC or FAP. Healthy individuals served as controls for skeletal muscle glutamine concentration. RESULTS: CONCLUSION: Patients with UC or FAP before surgical therapy do not suffer from glutamine depletion. IPAA resulted in changes in the distribution of glutamine and its metabolites in skeletal muscle, plasma, and ileal pouch mucosa, particularly in patients with UC. Further studies should investigate whether characteristics in the glutamine distribution have any impact for the long-term outcome after IPAA.
|
Authors | U A Heuschen, E H Allemeyer, U Hinz, K Langer, G Heuschen, C Decker-Baumann, C Herfarth, J Stern |
Journal | International journal of colorectal disease
(Int J Colorectal Dis)
Vol. 17
Issue 4
Pg. 245-52
(Jul 2002)
ISSN: 0179-1958 [Print] Germany |
PMID | 12073073
(Publication Type: Clinical Trial, Journal Article)
|
Chemical References |
|
Topics |
- Adenomatous Polyposis Coli
(metabolism, surgery)
- Case-Control Studies
- Colitis, Ulcerative
(metabolism, surgery)
- Female
- Glutamine
(metabolism)
- Humans
- Male
- Muscle, Skeletal
(metabolism)
- Proctocolectomy, Restorative
- Prospective Studies
|