Bone response to calcium phosphate-coated and bisphosphonate-immobilized titanium implants.

Abstract

Thin calcium phosphate (Ca-P) coatings have been introduced to overcome the shortcomings of plasma-sprayed Ca-P coatings. In our previous experiments, thin Ca-P coatings also enabled the immobilization of bisphosphonate, which is a drug used to treat osteoporosis. The present study was designed to evaluate the bone response to titanium implants treated with a thin Ca-P coating and bisphosphonate. Forty cylindrical commercially pure titanium implants with a length of 7 mm and a diameter of 3 mm were used as test implant fixtures. Three groups of surface-treated implants were prepared: (1) blasted with titanium powder and etched with a solution of 10% HF + 5% HNO3 (control); (2) modified with 0.5-microm thick Ca-P coatings and rapid heat-treating, and (3) immobilized with bisphosphonate by immersion in pamidronate disodium solution (10(-2) M) for 24 h at 37 degrees C. These surface-treated implants were inserted into edentulous areas in the mandibular molar region of five beagle dogs. After implantation periods of 4 and 12 weeks, the bone implant interface was evaluated histologically and histomorphometrically. All measurements were statistically evaluated using a one-way ANOVA and Fisher PLSD test for multiple comparisons among the means. Four weeks after the implantation, higher percentage of bone contact was found around the thin Ca-P-coated implants compared to that of the control group. The highest percentage of bone contact was found around the bisphosphonate-immobilized implants after 12 weeks of implantation. These data suggest that a thin coating of calcium phosphate followed by bisphosphonate-immobilization is effective in the promotion of osteogenesis on surfaces of dental implants.

• Authors: M Yoshinari, Y Oda, T Inoue, K Matsuzaka, M Shimono
• Journal: Biomaterials (Biomaterials) Vol. 23 Issue 14 Pg. 2879-85 (Jul 2002) ISSN: 0142-9612 [Print] Netherlands
• PMID: 12069328 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Calcium Phosphates
• Coated Materials, Biocompatible
• Dental Implants
• Diphosphonates
• alpha-tricalcium phosphate
• tetracalcium phosphate
• calcium phosphate, monobasic, anhydrous
• calcium phosphate
• Titanium
• calcium phosphate, dibasic, anhydrous

Topics

• Animals
• Bone and Bones (cytology, metabolism)
• Calcium Phosphates
• Coated Materials, Biocompatible (metabolism)
• Dental Implantation, Endosseous
• Dental Implants
• Diphosphonates
• Dogs
• Male
• Osseointegration (physiology)
• Prostheses and Implants
• Surface Properties
• Titanium
• X-Ray Diffraction