Life-threatening isradipine poisoning in a child.

Abstract

Calcium channel blockers as a group are responsible for significant morbidity and mortality with toxic exposures. Isradipine, a cardioselective dihydropyridine calcium channel blocker, rarely has been implicated, with only two reports in the literature of significant toxic reactions, one in an adult and another in a child. To our knowledge, we describe the first case of life-threatening isradipine poisoning in a child and provide documentation of serum drug levels. On arrival at the hospital, a 5-year-old girl had abdominal distention and bradycardia that rapidly progressed to asystole. She received 73 minutes of cardiopulmonary resuscitation and transvenous cardiac pacing and survived with an intact neurologic recovery. Serum concentrations of isradipine were 30-100 times those found with therapeutic use.

• Authors: Michael J Romano, Allyson Gaylor, Charlie J Sang Jr
• Journal: Pharmacotherapy (Pharmacotherapy) Vol. 22 Issue 6 Pg. 766-70 (Jun 2002) ISSN: 0277-0008 [Print] United States
• PMID: 12066967 (Publication Type: Case Reports, Journal Article)

Chemical References

• Calcium Channel Blockers
• Isradipine

Topics

• Bradycardia (chemically induced)
• Calcium Channel Blockers (adverse effects, blood, therapeutic use)
• Cardiac Pacing, Artificial
• Cardiopulmonary Resuscitation
• Child, Preschool
• Electrocardiography
• Female
• Humans
• Hypertension, Renal (complications, drug therapy, physiopathology)
• Isradipine (adverse effects, blood, therapeutic use)
• Liver Transplantation (physiology)
• Respiration, Artificial