Gestational trophoblastic disease.

Abstract

Patients diagnosed with molar pregnancy are treated by either suction curettage or hysterectomy, depending on their desire to preserve fertility. We use single-agent chemotherapy, preferably methotrexate, to treat low- or moderate-risk persistent trophoblastic tumors. High-risk patients who have metastatic disease are treated primarily with combination chemotherapy and, as indicated, adjuvant radiotherapy or surgery. We perform a hysterectomy in all cases of placental-site trophoblastic tumors; combination chemotherapy is used if there is evidence of metastatic disease.

• Authors: J O Schorge, D P Goldstein, M R Bernstein, R S Berkowitz
• Journal: Current treatment options in oncology (Curr Treat Options Oncol) Vol. 1 Issue 2 Pg. 169-75 (Jun 2000) ISSN: 1527-2729 [Print] United States
• PMID: 12057055 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents

Topics

• Adult
• Antineoplastic Agents (therapeutic use)
• Clinical Trials as Topic
• Combined Modality Therapy
• Female
• Humans
• Hysterectomy
• Pregnancy
• Prognosis
• Radiotherapy, High-Energy
• Remission Induction
• Trophoblastic Neoplasms (therapy)
• Uterine Neoplasms (therapy)