Beneficial effects of long-term administration of ONO-3144, a free radical scavenger, on stroke-prone SHR.

Abstract

UNLABELLED:

To clarify the preventive effects of ONO-3144, a free radical scavenger, on stroke-prone spontaneously hypertensive rats (SHRSP) and free radicals related to the hypertensive disorders.

METHODS:

Drugs with powdered chow were administered orally to the rats from 2- to 14-month-old. Body weight, blood pressure, rectal temperature, oxygen consumption rate, thyroid hormones, lipids, platelet number, ocular fundus, autopsy, and life span were investigated.

RESULTS:

ONO-3144 did not affect the growth, blood pressure, concentrations of thyroid hormones and lipids in the blood, but decreased the rectal temperature and oxygen consumption rate. ONO-3144 also prevented the platelet number decrease, sclerotic change of retinal artery, edematous and hypertrophic changes in parenchymal and circulatory organs. Both the average life-span and the longest life time of SHRSP given 40 mg/kg ONO-3144 were longer than those of normotensive rats and no administration hypertensive rats.

CONCLUSION:

The oxidative f ree radicals closely relate to hypertension-induced pathophysiological changes in SHRSP, and ONO-3144 prevents the changes of those disorders, and then brings longevity.

• Authors: Hideak Higashino, Kana Maeda, Masazumi Kawamoto, Hiroshi Endo, Wen-Hsiung Lee
• Journal: Acta pharmacologica Sinica (Acta Pharmacol Sin) Vol. 23 Issue 5 Pg. 393-8 (May 2002) ISSN: 1671-4083 [Print] United States
• PMID: 11978188 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Free Radical Scavengers
• Propiophenones
• 2-aminomethyl-4-tert-butyl-6-propionylphenol

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Arteriosclerosis (pathology, prevention & control)
• Free Radical Scavengers (administration & dosage, therapeutic use)
• Hypertension (pathology, prevention & control)
• Longevity (drug effects)
• Male
• Propiophenones (administration & dosage, therapeutic use)
• Rats
• Rats, Inbred SHR
• Rats, Inbred WKY
• Retinal Artery (pathology)
• Stroke (prevention & control)