Effect of necrotic tissue on progressive injury in deep partial thickness burn wounds.

Abstract

OBJECTIVE:

To evaluate the influence of necrotic tissue on progressive injury in deep partial thickness burn wounds.

METHODS:

Tissue specimens were cultured both for estimation of IL-8, EGF, bFGF, PDGF-AB and histopathological examination, from the pre-operation, post-operation, and non-operation wounds from seven patients with deep partial thickness burn.

RESULTS:

In seven specimens from the non-operation group, IL-8 release increased compared with those in the post-operation group (P < 0.001), while the levels of EGF, bFGF, PDGF-AB release were lower than those in the post-operation group. Histopathological examination revealed that in the non-operation group, the degree of neutrophil infiltration was enhanced, the extent of tissue necrosis enlarged, and residual skin appendages disappeared. In contrast, in the post-operation group, the degree of inflammatory response was decreased, with the formation of fresh granulation tissue and epithelialization.

CONCLUSION:

This study suggests that the presence of necrotic tissue could be the inhibitory factor in the wound healing process, as it might cause tissue progressive injury leading to the delay of wound healing. To promote wound healing, active tangential excision is recommended to remove necrotic tissue.

• Authors: Shuliang Lu, Jun Xiang, Chun Qing, Shuwen Jin, Zhenjiang Liao, Jixiang Shi
• Journal: Chinese medical journal (Chin Med J (Engl)) Vol. 115 Issue 3 Pg. 323-5 (Mar 2002) ISSN: 0366-6999 [Print] China
• PMID: 11940355 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-8

Topics

• Adult
• Burns (pathology, surgery)
• Humans
• Interleukin-8 (metabolism)
• Necrosis
• Skin (pathology)
• Wound Healing