Single-dose ciprofloxacin versus 3 days of norfloxacin in uncomplicated urinary tract infections in women.

Abstract

A double-blind, randomized controlled study to evaluate the efficacy and safety of a single dose of 500 mg of ciprofloxacin versus 3 days 400 mg twice-daily of norfloxacin in uncomplicated urinary tract infection in women was designed. Patients underwent four visits: baseline, and at 3, 7 and 28 days. The main efficacy variables were clinical and microbiological outcome at day 7. Analyses on both valid patients and intention-to-treat populations were performed. Two hundred and twenty-six patients (114 receiving ciprofloxacin and 112 receiving norfloxacin) were considered valid for efficacy evaluation. Bacteriologic cure was 91.2% in the ciprofloxacin group and 91.9% in the norfloxacin group. Clinical resolution was 91.2 and 93.8%, respectively. Both treatments were equally efficacious (P = 0.016).

• Authors: F Auquer, F Cordón, E Gorina, J C Caballero, C Adalid, J Batlle, Urinary Tract Infection Study Group
• Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases (Clin Microbiol Infect) Vol. 8 Issue 1 Pg. 50-4 (Jan 2002) ISSN: 1198-743X [Print] England
• PMID: 11906502 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents
• Ciprofloxacin
• Norfloxacin

Topics

• Adolescent
• Adult
• Aged
• Anti-Infective Agents (therapeutic use)
• Ciprofloxacin (adverse effects, therapeutic use)
• Double-Blind Method
• Female
• Humans
• Middle Aged
• Norfloxacin (adverse effects, therapeutic use)
• Treatment Outcome
• Urinary Tract Infections (drug therapy, microbiology)