Behavioral, hormonal and histological stress markers of anxiety-separation in postnatal rats are reduced by prepro-thyrotropin-releasing hormone 178-199.

Abstract	We investigated in the present study whether systemic injections of prepro-thyrotropin-releasing-hormone 178-199 (PPTRH 178-199) in postnatal 3-days old rat pups can provide ameliorative effects in a model of anxiety-separation disorder. The pups were individually separated from their mother and placed in a novel environment. PPTRH 178-199-treated animals started exploring the novel environment in a significantly shorter time and elicited significantly less distress vocalizations than control animals. PPTRH 178-199-treated animals also had markedly lower serum adrenocorticotropic hormone and corticosterone compared to control animals. Furthermore, we observed a significant increase in PPTRH 178-199 immunoreactive cell bodies in the hypothalamus of PPTRH 178-199-treated animals compared to controls, suggesting that the peptide crossed the blood-brain barrier. PPTRH 178-199 treatment can help to reduce behavioral and hormonal disturbances associated with anxiety-separation situations.
Authors	Christine E Stahl, Eva Redei, Yun Wang, Cesario V Borlongan
Journal	Neuroscience letters (Neurosci Lett) Vol. 321 Issue 1-2 Pg. 85-9 (Mar 15 2002) ISSN: 0304-3940 [Print] Ireland
PMID	11872263 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References	Hormones Peptide Fragments Protein Precursors prepro-thyrotropin-releasing hormone (178-199) Thyrotropin-Releasing Hormone Adrenocorticotropic Hormone Corticosterone
Topics	Adrenocorticotropic Hormone (blood) Animals Animals, Newborn Anxiety, Separation (drug therapy, metabolism, physiopathology) Behavior, Animal (drug effects, physiology) Corticosterone (blood) Disease Models, Animal Exploratory Behavior (drug effects, physiology) Hormones (blood) Immunohistochemistry Maternal Deprivation Neurons (drug effects, metabolism) Paraventricular Hypothalamic Nucleus (drug effects, metabolism) Peptide Fragments (pharmacology) Protein Precursors (pharmacology) Rats Rats, Sprague-Dawley Stress, Psychological (drug therapy, metabolism, physiopathology) Thyrotropin-Releasing Hormone (pharmacology) Vocalization, Animal (drug effects, physiology)

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