Ethnic comparison of weight loss in the Trial of Nonpharmacologic Interventions in the Elderly.

Abstract

OBJECTIVE:

To compare weight loss in blacks and whites in the Trial of Nonpharmacologic Interventions in the Elderly (TONE).

RESEARCH METHODS AND PROCEDURES:

TONE enrolled 421 overweight white and 164 overweight black adults, 60 to 79 years old, with blood pressure well-controlled on a single, antihypertensive drug. Drug therapy withdrawal was attempted 3 months after randomization to counseling for weight loss, sodium reduction, both weight loss and sodium reduction, or to usual care, with follow-up for 15 to 36 months after enrollment. Statistical procedures included repeated measures analysis of covariance and logistic and proportional hazards regression.

RESULTS:

In the weight-loss condition, net weight change (in kilograms) was -2.7 in blacks and -5.9 in whites (p < 0.001; ethnic difference, p = 0.0002) at 6 months and -2.0 (p < 0.05) in blacks and -4.9 (p < 0.001) in whites at the end of follow-up (ethnic difference, p = 0.007). In weight/sodium, net weight change was -2.1 (p < 0.01) in blacks and -2.8 (p < 0.001) in whites at 6 months, and -1.9 in blacks and -1.7 in whites at the end of follow-up (p < 0.05; ethnic difference, p > 0.5). Exploratory analyses suggested a more favorable pattern of weight change in blacks than in whites from 6 months onward. There was no ethnic difference in blood pressure outcomes.

DISCUSSION:

Whites lost more weight than blacks without, but not with, a concurrent focus on sodium reduction.

• Authors: Shiriki K Kumanyika, Mark A Espeland, Judy L Bahnson, Juliene B Bottom, Jeanne B Charleston, Steve Folmar, Alan C Wilson, Paul K Whelton, TONE Cooperative Research Group
• Journal: Obesity research (Obes Res) Vol. 10 Issue 2 Pg. 96-106 (Feb 2002) ISSN: 1071-7323 [Print] United States
• PMID: 11836455 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antihypertensive Agents

Topics

• Aged
• Aging
• Alcohol Drinking
• Antihypertensive Agents (administration & dosage, therapeutic use)
• Black People
• Blood Pressure
• Counseling
• Diet, Sodium-Restricted
• Female
• Humans
• Hypertension (therapy)
• Male
• Middle Aged
• Smoking (epidemiology)
• Time Factors
• Weight Loss
• White People