Serum levels of macrophage colony-stimulating factor and aortic calcification in hemodialysis patients.

Abstract	Hemodialysis (HD) patients have accelerated atherosclerosis. Recent reports have shown that aortosclerosis is more frequently observed in HD patients than in healthy subjects. Macrophage colony-stimulating factor (M-CSF) secreted by activated macrophages may be involved in the process of aortosclerosis in HD patients. To understand the mechanism behind the increased incidence of aortosclerosis in HD patients, we examined the relationships between serum M-CSF levels and aortic calcification index (ACI) estimated by CT scan. A significant increase in serum M-CSF concentrations was found in HD patients (3.8 +/- 0.2 ng/ml) as compared with controls (1.5 +/- 0.1 ng/ml). No significant differences were observed between chronic glomerulonephritis and diabetes mellitus groups of patients. We also found no significant differences between the groups using different membranes (triacetate 3.8 +/- 0.2 ng/ml vs. polysulfone 3.8 +/- 0.4 ng/ml). There was no correlation between serum M-CSF concentrations and clinical parameters such as age, duration of HD, blood pressure, serum concentrations of nitrogen, creatinine, cholesterol, triglyceride, LDL, Ca x P products, and intact parathyroid hormone. A positive correlation was observed between serum M-CSF levels and ACI in HD patients (r = 0.596, p < 0.01). These results suggest that M-CSF may be involved in the process of aortosclerosis in HD patients.
Authors	K Nitta, T Akiba, A Kawashima, N Kimata, N Miwa, K Uchida, K Honda, T Takei, S Otsubo, W Yumura, T Kabaya, H Nihei
Journal	American journal of nephrology (Am J Nephrol) 2001 Nov-Dec Vol. 21 Issue 6 Pg. 465-70 ISSN: 0250-8095 [Print] Switzerland
PMID	11799263 (Publication Type: Journal Article)
Copyright	Copyright 2001 S. Karger AG, Basel
Chemical References	Macrophage Colony-Stimulating Factor
Topics	Aortic Diseases (diagnostic imaging) Calcinosis (diagnostic imaging) Enzyme-Linked Immunosorbent Assay Female Humans Longitudinal Studies Macrophage Colony-Stimulating Factor (blood) Male Middle Aged Prospective Studies Renal Dialysis Statistics, Nonparametric Tomography, X-Ray Computed

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