Use of real-time magnetic resonance guidance to assist bone biopsy in pediatric malignancy.

Abstract

Magnetic resonance (MR) imaging (MRI) has the advantage of demonstrating lesions not visualized by other radiologic modalities. We present a case involving pediatric malignancy where MR-guided bone biopsy confirmed correct histologic diagnosis and was used to plan additional treatment. A 2-year, 9-month-old boy had a history of spontaneous regression of stage 4S neuroblastoma. (123)I-metaiodobenzylguanidine scintigraphy showed a hot spot at his right lower leg; however, neither plain radiograph (99m)Tc diphosphonate bone scan was positive. Only MRI depicted a lesion at the distal third of his right tibia, and a subsequent MR-guided bone biopsy was diagnostic of bone marrow metastasis. After 6 courses of intensive chemotherapy, he has been in complete remission. MR-guided biopsy technique is likely to be particularly useful for the resection of invisible metastatic lesions, especially those that are only visible using MRI.

• Authors: Shigeru Ueno, Seishichi Yokoyama, Hitoshi Hirakawa, Hiromasa Yabe, Yutaka Suzuki, Hideki Atsumi, Mitsunori Matsumae
• Journal: Pediatrics (Pediatrics) Vol. 109 Issue 1 Pg. E18 (Jan 2002) ISSN: 1098-4275 [Electronic] United States
• PMID: 11773586 (Publication Type: Case Reports, Journal Article)

Chemical References

• Biomarkers, Tumor

Topics

• Adrenal Gland Neoplasms (pathology)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biomarkers, Tumor (analysis)
• Biopsy (methods)
• Bone Neoplasms (pathology, secondary)
• Child, Preschool
• Humans
• Liver Neoplasms (secondary)
• Magnetic Resonance Imaging (methods)
• Male
• Neoplasm Regression, Spontaneous
• Neuroblastoma (diagnosis, secondary)
• Remission Induction (methods)
• Skin Neoplasms (secondary)