Inhibitory effect of magnolol and honokiol from Magnolia obovata on human fibrosarcoma HT-1080. Invasiveness in vitro.

Abstract

We investigated the inhibitory effect of Magnolia obovata Thunb. bark ethanol extracts on human fibrosarcoma HT-1080 cells invasion in a reconstituted basement membrane [Matrigel (MG)]. We found that the effective components of the bark ethanol extracts were magnolol and honokiol, two biphenyl compounds. The extracts, magnolol and honokiol, did not affect HT-1080 cells adhesion to MG, but did inhibit HT-1080 cells migration at a high concentration (100 microM). HT-1080 cells secrete matrix metalloproteinase (MMP)-9, which degrades the extracellular matrix as a part of the invasive process. Magnolol and honokiol inhibited the activity of MMP-9, which may have been responsible, in part, for the inhibition of tumor cell invasiveness.

• Authors: H Nagase, K Ikeda, Y Sakai
• Journal: Planta medica (Planta Med) Vol. 67 Issue 8 Pg. 705-8 (Nov 2001) ISSN: 0032-0943 [Print] Germany
• PMID: 11731909 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Biphenyl Compounds
• Lignans
• Matrix Metalloproteinase Inhibitors
• magnolol
• honokiol

Topics

• Antineoplastic Agents, Phytogenic (therapeutic use)
• Biphenyl Compounds (chemistry, therapeutic use)
• Fibrosarcoma (drug therapy)
• Humans
• Lignans
• Magnoliaceae (chemistry)
• Matrix Metalloproteinase Inhibitors
• Neoplasm Invasiveness
• Phytotherapy
• Plant Bark (chemistry)
• Tumor Cells, Cultured