Purine receptor agonists protect the genome of plant and animal cells from clastogen damage.

Abstract

Purine receptor agonists adenosine, cyclohexyladenosine, phenylisopropyladenosine, dimethylaminopurine riboside, ATP, and ADP reduced the level of chromosome aberrations and the number of micronuclei induced by ethylmethane sulfonate and cyclophosphamide in plants (Crepis capillaris) and mice. Possible mechanisms of the protective effect of these ligands are discussed.

• Authors: V S Kharitonov, V V Semenov, B I Barabanshchikov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 132 Issue 1 Pg. 666-9 (Jul 2001) ISSN: 0007-4888 [Print] United States
• PMID: 11687849 (Publication Type: Journal Article)

Chemical References

• Ligands
• Mutagens
• Purinergic Agonists
• Receptors, Purinergic
• Cyclophosphamide
• Ethyl Methanesulfonate

Topics

• Animals
• Bone Marrow Cells (drug effects, physiology)
• Chromosome Aberrations
• Crepis (drug effects, genetics)
• Cyclophosphamide (pharmacology)
• Erythrocytes (drug effects, metabolism)
• Ethyl Methanesulfonate (pharmacology)
• Humans
• Ligands
• Male
• Mice
• Micronuclei, Chromosome-Defective
• Micronucleus Tests
• Mutagenesis
• Mutagenicity Tests
• Mutagens (pharmacology)
• Purinergic Agonists
• Receptors, Purinergic (metabolism)