Abstract | BACKGROUND: In the current study we focused on changes in the immune parameters of patients with CF after lung transplantation (Tx), with particular emphasis on the interaction of the immune system, infection, the autoimmune phenomenon observed in some CF patients, and immunosuppression. MATERIAL AND METHODS: Seven transplant patients with CF were investigated, 3 men and 4 women; the average age at Tx was 24.2 years (20.2-32.3). The parameters of both humoral immunity ( immunoglobulins, complement, CRP, antinuclear and antineutrophil cytoplasmic antibodies) and cellular immunity (T and B lymphocytes, NK cells) were traced. RESULTS: CONCLUSIONS: In our series of CF lung transplant recipients, we found Burkholderia cepacia infection to be a risk factor. The robust appearance of autoantibodies and their persistent positivity for many months despite deep immunosuppression is a remarkable feature observed in some CF patients.
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Authors | A Sedivá, R Lischke, J Simonek, J Tkaczyk, V Vávrová, J Bartosová, P Pohunek, J Bartůnková, P Pafko |
Journal | Medical science monitor : international medical journal of experimental and clinical research
(Med Sci Monit)
2001 Nov-Dec
Vol. 7
Issue 6
Pg. 1219-23
ISSN: 1234-1010 [Print] United States |
PMID | 11687733
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Autoimmunity
- Cystic Fibrosis
(therapy)
- Female
- Fluorescent Antibody Technique
- Graft Rejection
- Humans
- Immunity, Cellular
- Lung Transplantation
(immunology)
- Male
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