Abstract |
Molecular biological techniques have begun to transform modern medicine. These techniques have shown promise in the pathological diagnosis of difficult or uncommon tumors. Accurate molecular diagnosis of the small round-cell tumors, for example, is especially important because divergent therapies may be required to eradicate such disparate lesions as neuroblastoma, lymphoma, rhabdomyosarcoma, central primitive neuroectodermal tumors/ medulloblastoma, or Ewing sarcoma (ES). The authors present an unusual case of a primary, extraosseous ES arising from the intramedullary spinal cord, in which molecular studies were required for specific diagnosis and therapeutic guidance.
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Authors | R J Weil, Z Zhuang, S Pack, S Kumar, L Helman, B G Fuller, C L Mackall, E H Oldfield |
Journal | Journal of neurosurgery
(J Neurosurg)
Vol. 95
Issue 2 Suppl
Pg. 270-5
(Oct 2001)
ISSN: 0022-3085 [Print] United States |
PMID | 11599852
(Publication Type: Case Reports, Journal Article)
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Topics |
- Adult
- Cytogenetic Analysis
- Humans
- Immunohistochemistry
- In Situ Hybridization, Fluorescence
- Male
- Reverse Transcriptase Polymerase Chain Reaction
- Sarcoma, Ewing
(diagnosis, pathology, surgery)
- Spinal Cord Neoplasms
(diagnosis, pathology, surgery)
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