Abstract | OBJECTIVE: To investigate the pharmacokinetics and toxicity of intravitreal chemotherapeutic agents in the rabbit eye for the potential treatment of primary intraocular lymphoma and other intraocular malignancies. METHODS: The ocular pharmacokinetics of intravitreal methotrexate sodium (400 microg) was studied in 10 New Zealand white rabbits, and a single-compartment, first-order elimination model was used to calculate the drug half-life. With the use of these data, a treatment schedule using serial injections of intravitreal methotrexate and single injections of fluorouracil and dexamethasone sodium phosphate was developed. This schedule was studied in 4 New Zealand white rabbits to explore the combined toxicity of these agents. RESULTS: CONCLUSIONS: CLINICAL RELEVANCE: Although responsive to conventional chemotherapy or radiotherapy, recurrence of ocular involvement with primary central nervous system lymphoma occurs in more than 50% of treated cases. Anecdotal reports of the use of intravitreal chemotherapy for primary intraocular lymphoma have been encouraging. However, animal data on the pharmacokinetics and toxicity of combined intravitreal agents for the treatment of this disease are lacking.
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Authors | G Velez, P Yuan, C Sung, G Tansey, G F Reed, C C Chan, R B Nussenblatt, M R Robinson |
Journal | Archives of ophthalmology (Chicago, Ill. : 1960)
(Arch Ophthalmol)
Vol. 119
Issue 10
Pg. 1518-24
(Oct 2001)
ISSN: 0003-9950 [Print] United States |
PMID | 11594954
(Publication Type: Journal Article)
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Chemical References |
- Dexamethasone
- Fluorouracil
- Methotrexate
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Topics |
- Animals
- Antineoplastic Combined Chemotherapy Protocols
(pharmacokinetics, toxicity)
- Biological Availability
- Chromatography, High Pressure Liquid
- Dexamethasone
(administration & dosage)
- Electroretinography
(drug effects)
- Eye Neoplasms
(drug therapy)
- Female
- Fluorouracil
(administration & dosage)
- Half-Life
- Lymphoma
(drug therapy)
- Male
- Methotrexate
(administration & dosage)
- Rabbits
- Retina
(drug effects, pathology)
- Vitreous Body
(metabolism)
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