Synoviorthesis with radioactive Yttrium in haemophilia: Israel experience.

Abstract

Radioactive Yttrium-90 (90Y) was injected into 163 joints. Of these patients 115 were persons with haemophilia and they suffered from recurrent haemarthroses. The median age at the time of the initial exposure to 90Y was between 11 and 15 years and the median follow-up period 11 years. Over 80% of the patients with haemophilia reported a decrease in the number of haemarthroses and 15% stopped bleeding altogether in the treated articulation. The safety of this modality of management has been reported and hence the patients age should not be regarded as a criteria.

• Authors: M Heim, E Goshen, Y Amit, U Martinowitz
• Journal: Haemophilia : the official journal of the World Federation of Hemophilia (Haemophilia) Vol. 7 Suppl 2 Pg. 36-9 (Jul 2001) ISSN: 1351-8216 [Print] England
• PMID: 11564144 (Publication Type: Journal Article)

Chemical References

• Yttrium Radioisotopes

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Follow-Up Studies
• Hemarthrosis (complications, drug therapy, etiology)
• Hemophilia A (complications, pathology, therapy)
• Humans
• Infant
• Injections, Intra-Articular
• Israel
• Middle Aged
• Retrospective Studies
• Synovitis (etiology, pathology, radiotherapy)
• Treatment Outcome
• Yttrium Radioisotopes (administration & dosage, therapeutic use)