Antiinflammatory activity of alpha-methyl-3-phenyl-7-benzofuranacetic acid (R-803).

Abstract

The antiinflammatory activity of R-803 (alpha-methyl-3-phenyl-7-benzofuranacetic acid), a new nonsteroidal drug, has been demonstrated. The oral administration of R-803 inhibits carrageenan-induced edema of the rat's paw, ultraviolet-induced erythema of guinea-pig skin, adjuvant-induced and 6-sulfonamidoindazole-induced arthritides of the rat at doses in the range of 1.0 to 6.0 mg/kg. It also inhibits the cotton pellet-induced granuloma in the rat at higher doses.

• Authors: K F Swingle, R A Scherrer, T J Grant
• Journal: Archives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) Vol. 214 Issue 2 Pg. 240-9 (Apr 1975) ISSN: 0003-9780 [Print] Belgium
• PMID: 1156032 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Benzofurans
• enprofen

Topics

• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Arthritis (drug therapy)
• Benzofurans (therapeutic use)
• Edema (drug therapy)
• Erythema (drug therapy)
• Female
• Granuloma (drug therapy)
• Guinea Pigs
• Male
• Radiation Injuries, Experimental (drug therapy)
• Rats
• Ultraviolet Rays