Abstract | BACKGROUND: The progression to endocrine therapy-resistant prostate cancer is partly due to clonal change to neuroendocrine cell tumor. To elucidate this pathologic process, the clinical courses of four cases of neuroendocrine cell tumor that were found at autopsy are reported. METHODS: RESULTS: The outstanding features of the neuroendocrine cell tumors were: (i) survival was brief after relapse, although the duration of control by employing endocrine therapy varied; (ii) the prostate-specific antigen level did not increase after relapse; and (iii) the sites of metastasis were similar to those of common adenocarcinomas. CONCLUSION: The progression to a neuroendocrine cell tumor indicated a poor prognosis and slight (if any) changes in the serum prostate-specific antigen level. This tumor might not appear to respond to any therapeutic attempt.
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Authors | M Tanaka, Y Suzuki, K Takaoka, N Suzuki, S Murakami, O Matsuzaki, J Shimazaki |
Journal | International journal of urology : official journal of the Japanese Urological Association
(Int J Urol)
Vol. 8
Issue 8
Pg. 431-6; discussion 437
(Aug 2001)
ISSN: 0919-8172 [Print] Australia |
PMID | 11555007
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Aged
- Aged, 80 and over
- Carcinoma, Neuroendocrine
(pathology)
- Disease Progression
- Humans
- Male
- Prostatic Neoplasms
(pathology)
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