Combined modality treatment for locally advanced squamous-cell carcinoma of the oropharynx in a woman with Bloom's syndrome: a case report and review of the literature.

Abstract

We describe a case of locally advanced unresectable squamous-cell carcinoma of the oropharynx in a young woman with Bloom's syndrome. She was treated with radical radiation therapy and concurrent chemotherapy (cisplatin and 5-flurouracil). She was unable to complete treatment due to the development of severe side effects: confluent mucositis, moist desquamating skin reaction, severe diarrhea and severe myelosupression with neutropenic sepsis. The limited relevant literature is presented. We conclude that chemotherapy should be used with extreme caution in Bloom's syndrome patients.

• Authors: B Ma, J Corry, D Rischin, T Leong, L J Peters
• Journal: Annals of oncology : official journal of the European Society for Medical Oncology (Ann Oncol) Vol. 12 Issue 7 Pg. 1015-7 (Jul 2001) ISSN: 0923-7534 [Print] England
• PMID: 11521786 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Antimetabolites, Antineoplastic
• Cisplatin
• Fluorouracil

Topics

• Adult
• Antimetabolites, Antineoplastic (adverse effects)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Bloom Syndrome (complications)
• Carcinoma, Squamous Cell (complications, drug therapy, radiotherapy, therapy)
• Chemotherapy, Adjuvant
• Cisplatin (adverse effects)
• Female
• Fluorouracil (adverse effects)
• Humans
• Neoplasm Invasiveness
• Oropharyngeal Neoplasms (complications, drug therapy, radiotherapy, therapy)
• Radiotherapy, Adjuvant