The phosphatidylserine receptor: a crucial molecular switch?

Abstract

The uptake and removal of necrotic or lysed cells involves inflammation and an immune response, due in part to processes that involve members of the collectin family, surface calreticulin and CD91. Clearance of apoptotic cells, by contrast, does not induce either inflammation or immunity. Could the phosphatidylserine receptor be the molecular switch that determines what the outcome will be?

• Authors: P M Henson, D L Bratton, V A Fadok
• Journal: Nature reviews. Molecular cell biology (Nat Rev Mol Cell Biol) Vol. 2 Issue 8 Pg. 627-33 (Aug 2001) ISSN: 1471-0072 [Print] England
• PMID: 11483996 (Publication Type: Comparative Study, Journal Article, Review)

Chemical References

• Calcium-Binding Proteins
• Calreticulin
• Carrier Proteins
• Collectins
• Inflammation Mediators
• Low Density Lipoprotein Receptor-Related Protein-1
• Membrane Lipids
• Phosphatidylserines
• Receptors, Cell Surface
• Receptors, Immunologic
• Ribonucleoproteins
• Transforming Growth Factor beta
• phosphatidylserine receptor
• JMJD6 protein, human
• Jumonji Domain-Containing Histone Demethylases
• Endopeptidases

Topics

• Animals
• Antigen Presentation
• Apoptosis (physiology)
• Calcium-Binding Proteins (physiology)
• Calreticulin
• Carrier Proteins (physiology)
• Cell Adhesion
• Cell Death (physiology)
• Cellular Senescence
• Collectins
• Dendritic Cells (physiology)
• Endopeptidases (physiology)
• Humans
• Inflammation
• Inflammation Mediators (metabolism)
• Jumonji Domain-Containing Histone Demethylases
• Low Density Lipoprotein Receptor-Related Protein-1
• Membrane Lipids (physiology)
• Models, Biological
• Necrosis
• Phagocytosis (physiology)
• Phosphatidylserines (physiology)
• Receptors, Cell Surface (physiology)
• Receptors, Immunologic (physiology)
• Ribonucleoproteins (physiology)
• Transforming Growth Factor beta (physiology)