Abstract | OBJECTIVES: DESIGN: Prospective, controlled animal study. SETTING: A university research laboratory. SUBJECTS: MEASUREMENTS AND MAIN RESULTS: CONCLUSIONS: These findings suggest that, despite high plasma levels of endogenous corticotropin, adrenal dysfunction, as indicated by the reduction of corticotropin-induced plasma corticosterone release and adrenal contents of cAMP as well as the decreased adrenal levels of corticosterone, occurs during the late stage of polymicrobial sepsis. Therefore, the recognition of adrenal insufficiency and interventions to improve adrenal responsiveness may be beneficial in improving the outcome during late sepsis.
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Authors | D J Koo, D Jackman, I H Chaudry, P Wang |
Journal | Critical care medicine
(Crit Care Med)
Vol. 29
Issue 3
Pg. 618-22
(Mar 2001)
ISSN: 0090-3493 [Print] United States |
PMID | 11373430
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Sodium Chloride
- Adrenocorticotropic Hormone
- Cyclic AMP
- Corticosterone
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Topics |
- Adrenal Glands
(chemistry)
- Adrenal Insufficiency
(blood, diagnosis, microbiology, therapy)
- Adrenocorticotropic Hormone
(blood)
- Animals
- Bacterial Infections
(complications, microbiology, therapy)
- Cecum
(surgery)
- Corticosterone
(analysis, blood)
- Cyclic AMP
(analysis)
- Disease Models, Animal
- Incidence
- Ligation
- Male
- Prognosis
- Prospective Studies
- Punctures
- Rats
- Rats, Sprague-Dawley
- Risk Factors
- Sepsis
(complications, microbiology, therapy)
- Sodium Chloride
- Time Factors
- Treatment Outcome
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