Raised platelet thiobarbituric acid-reacting substances in proliferative Eales' disease.

Abstract

BACKGROUND:

Platelets are an elective site for oxidative stress owing to their high content of polyunsaturated fatty acid. Increased lipid peroxidation and elevated platelet thiobarbituric acid-reacting substances (TBARS) signal oxidative stress. This possibly leads to retinal neovascularization in Eales' disease.

METHODS:

TBARS levels were estimated in consecutive cases of Eales' disease with neovascularisation (n = 26), Eales' disease without neovascularisation (n = 17) and healthy controls (n = 17).

RESULTS:

Platelet TBARS levels in the cases of Eales' disease with neovascularisation, Eales' disease without neovascularisation, and healthy controls were 0.66 +/- 0.1, 0.57 +/- 0.11 and 0.42 +/- 0.14 n moles TBARS formed/hour/10(8) platelets respectively. Student's t-test showed a significant increase in platelet TBARS levels in cases with neovascularisation as compared to cases without neovascularization (p < 0.05) and healthy controls (p < 0.01).

CONCLUSION:

The increase in platelet TBARS levels in proliferative Eales' disease is consistent with an emerging view that lipid peroxides may be associated with retinal neovascularisation.

• Authors: P Srivastava, S Saxena, V K Khanna, D Kumar, R Nath, P K Seth
• Journal: Indian journal of ophthalmology (Indian J Ophthalmol) Vol. 48 Issue 4 Pg. 307-9 (Dec 2000) ISSN: 0301-4738 [Print] India
• PMID: 11340890 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Lipid Peroxides
• Thiobarbituric Acid Reactive Substances

Topics

• Adolescent
• Adult
• Biomarkers (blood)
• Blood Platelets (metabolism)
• Disease Progression
• Humans
• Lipid Peroxidation (physiology)
• Lipid Peroxides (blood)
• Retinal Diseases (blood, complications, pathology)
• Retinal Neovascularization (blood, etiology, pathology)
• Thiobarbituric Acid Reactive Substances (metabolism)
• Vasculitis (blood, complications, pathology)