[A case of docetaxel-resistant breast cancer responsive to paclitaxel therapy].

Abstract

A 73-year-old woman underwent docetaxel therapy for lung metastasis from breast cancer after having received CAF therapy. Because of the progressive disease due to secondary resistance to docetaxel, the patient was given three courses of paclitaxel therapy (60 mg/m2, day 1, 8, 15 and 22, repeated every 6 weeks). The paclitaxel therapy brought about no adverse effects and a 51%-reduction in the size of the metastatic lung tumor (PR). Although the duration of the response to the paclitaxel therapy was limited to about one month due to progression of a brain metastasis, paclitaxel therapy may be effective against docetaxel-resistant breast cancer.

• Authors: S Oura, H Tanino, T Yoshimasu, T Sakurai, T Nakamura, Y Kokawa, K Matsuyama, Y Naito
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 28 Issue 4 Pg. 511-4 (Apr 2001) ISSN: 0385-0684 [Print] Japan
• PMID: 11329786 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Taxoids
• Docetaxel
• Paclitaxel

Topics

• Aged
• Antineoplastic Agents, Phytogenic (administration & dosage, therapeutic use)
• Brain Neoplasms (secondary)
• Breast Neoplasms (drug therapy, pathology)
• Docetaxel
• Drug Administration Schedule
• Drug Resistance, Neoplasm
• Female
• Humans
• Lung Neoplasms (secondary)
• Paclitaxel (administration & dosage, analogs & derivatives, pharmacology, therapeutic use)
• Taxoids