Association analysis between two functional dopamine D2 receptor gene polymorphisms and schizophrenia.

Abstract

The dopamine D2 receptor (DRD2) gene has been listed as one of the candidate genes for susceptibility to schizophrenia. To date, a significant association between schizophrenia and two functional DRD2 gene polymorphisms, Ser311Cys and -141C Ins/Del, in Japanese samples, has been reported by Arinami et al. [1994: Lancet 343:703-704; 1997: Hum Mol Genet 6:577-582]. In the present study, we replicated the findings of Arinami et al. [1994: Lancet 343:703-704; 1997: Hum Mol Genet 6:577-582] in the same ethnic groups (Japanese samples) with the same polymorphisms (Ser311Cys and -141C Ins/Del). We genotyped these two polymorphisms for 241 patients and for 201 controls. Neither polymorphism was associated with schizophrenia. Moreover, in a haplotype analysis of the present sample, combined pairs of two polymorphisms provided no evidence for the association of either haplotype with schizophrenia. Our findings indicate that an association between the two functional DRD2 gene polymorphisms, Ser311Cys and -141C Ins/Del, and schizophrenia is unlikely.

• Authors: H Hori, O Ohmori, T Shinkai, H Kojima, J Nakamura
• Journal: American journal of medical genetics (Am J Med Genet) Vol. 105 Issue 2 Pg. 176-8 (Mar 08 2001) ISSN: 0148-7299 [Print] United States
• PMID: 11304833 (Publication Type: Journal Article)
• Copyright: Copyright 2001 Wiley-Liss, Inc.

Chemical References

• Receptors, Dopamine D2

Topics

• Aged
• Case-Control Studies
• Female
• Gene Deletion
• Genotype
• Haplotypes
• Humans
• Japan
• Male
• Middle Aged
• Models, Statistical
• Polymorphism, Genetic
• Receptors, Dopamine D2 (genetics)
• Schizophrenia (genetics)