Abstract | OBJECTIVE:
Osteoporosis, common in European and South American adults with celiac disease, has not been reported in those patients with celiac disease residing in North America. We therefore evaluated bone density in a group of patients from the United States. METHODS: Patients (105 women and 23 men) with celiac disease, who had completed a questionnaire and had bone mineral density (BMD) measured by dual energy x-ray absorptiometry, were evaluated. The patients were an average age of 56 yr old (range 21-83 yr) and had been on a gluten-free diet from 0 months to 46 yr (mean 7.5 yr). RESULTS:
Osteoporosis (T score < -2.5) was present in 34% of the patients at the lumbar spine, 27% at the femoral neck, and 36% at the radius. Low bone mass (T score between -1.0 and -2.5) was present in 38% at the lumbar spine, 44% at the femoral neck, and 32% at the radius. When compared to age-matched controls, men were more severely affected than women. BMD did not differ between those on a gluten-free diet and those who had not begun therapy. BMD was remeasured 16 +/- 2 months after beginning a gluten-free diet in 5 patients; it increased by 7.5% at the femoral neck (p < 0.02). In 16 patients who had followed a gluten-free diet for an average of 12 yr, BMD remained stable over an additional 2 yr of observation. CONCLUSIONS:
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Authors | D Meyer, S Stavropolous, B Diamond, E Shane, P H Green |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 96
Issue 1
Pg. 112-9
(Jan 2001)
ISSN: 0002-9270 [Print] United States |
PMID | 11197239
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Absorptiometry, Photon
- Adult
- Age Distribution
- Aged
- Aged, 80 and over
- Bone Density
- Celiac Disease
(diagnosis, epidemiology)
- Comorbidity
- Female
- Health Surveys
- Humans
- Incidence
- Linear Models
- Male
- Middle Aged
- North America
(epidemiology)
- Osteoporosis
(diagnosis, epidemiology)
- Risk Factors
- Sex Distribution
- Statistics, Nonparametric
- Surveys and Questionnaires
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