A study to assess the plaque inhibitory action of a newly formulated triclosan toothpaste.

Abstract

BACKGROUND/AIMS:

Triclosan containing toothpastes have been noted for their potential to inhibit plaque and gingival inflammation. The aim of this study was to determine whether a toothpaste containing triclosan and an enhanced fluoride system would inhibit de novo plaque formation beyond that of a non-triclosan, conventional fluoride toothpaste.

METHODS:

This study used a 4-day plaque regrowth model in which 24 volunteers used toothpaste rinses as the only form of oral hygiene. Following a prophylaxis and a single brushing with the toothpastes, 2x daily rinsing with toothpaste slurries was used over the following 96 h.

RESULTS:

After 24 h, there was no difference in plaque area between the triclosan paste and its control paste. After 96 h, a reduction in plaque score of 5% was noted for the test toothpaste compared to the control paste which was statistically significant (p=0.028). For plaque area this reduction was increased to 16%, which was also significant (p=0.006).

CONCLUSIONS:

These findings would appear to warrant further investigation into the potential value of the paste in inhibiting both plaque and gingivitis.

• Authors: J Moran, M Addy, R G Newcombe, I Marlow
• Journal: Journal of clinical periodontology (J Clin Periodontol) Vol. 28 Issue 1 Pg. 86-9 (Jan 2001) ISSN: 0303-6979 [Print] United States
• PMID: 11142672 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Infective Agents, Local
• Toothpastes
• Triclosan

Topics

• Adult
• Anti-Infective Agents, Local (therapeutic use)
• Cross-Over Studies
• Dental Plaque (prevention & control)
• Double-Blind Method
• Female
• Humans
• Male
• Statistics, Nonparametric
• Toothpastes (therapeutic use)
• Triclosan (therapeutic use)