Abstract |
A 23-year-old male suffering from severe aplastic anemia (SAA) weighing 60 kg was successfully treated by unrelated allo-CBSCT ( cord blood stem cell transplantation). A six-loci HLA-identical umbilical cord blood (UCB) was infused after conditioning with low-dose cyclophosphamide (CTX) and antilymphocyte globulin (ALG). The prophylaxis of GVHD consisted of CsA and MTX. The infused cord blood provided 1.89 x 10(7) nucleated cells per kg, CD34-positive cells: 0.89%. Neutrophils >0.5 x 10(9)/l were reached 10 days after transplant, and platelets greater than 50.0 x 10(9)/l at day 26. RBC and platelet transfusion independence were reached on days 15 and 18. The patient developed grade 1 skin GVHD 10 months after engraftment of the donor cells. Microsatellite DNA fingerprinting indicated a stable and persistent donor-recipient mixed chimerism, whilst the circulating red cells remain of host origin.
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Authors | P Mao, C Liao, Z Zhu, H Wang, S Wang, Y Xu, W Mo, Y Ying, Q Li, B Liu |
Journal | Bone marrow transplantation
(Bone Marrow Transplant)
Vol. 26
Issue 10
Pg. 1121-3
(Nov 2000)
ISSN: 0268-3369 [Print] England |
PMID | 11108315
(Publication Type: Case Reports, Journal Article)
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Topics |
- Adult
- Anemia, Aplastic
(therapy)
- Fetal Blood
(cytology)
- Graft vs Host Disease
(etiology)
- Hematopoietic Stem Cell Transplantation
- Histocompatibility Testing
- Humans
- Male
- Transplantation, Homologous
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