[Three cases of metastatic breast cancer, resistant to pre-chemo and/or endocrine therapy, markedly improved with UFT and cyclophosphamide oral combination therapy].

The cases of 3 female patients with metastatic breast cancer treated with oral UFT and cyclophosphamide (CPA) are reported. Patient 1 had lymph node and bone metastases. Patient 2 had bone metastasis. Patient 3 had skin, lymph node, and peritoneal metastases. All had a history of mastectomy and chemo- and/or endocrine therapy for metastatic lesions. Patients 2 and 3 had also undergone CAF combination chemotherapy. However, the lesions did not change. UFT 400 mg and CPA 100 mg, everyday, were administered to patient 1. UFT 400 mg and CPA 100 mg, 2 weeks, and UFT 400 mg, 2 weeks, were given every 4 weeks to patient 2. UFT 300 mg and CPA 150 mg, 6 weeks per 8 weeks were given to patient 3. Improvements in the metastatic lesions were seen 4 weeks after the beginning of UFT and CPA therapy. Therapy is now continuing, and no patients had a progression of the disease. All had leukopenia 2 or 4 weeks after the beginning of this therapy, and two temporarily stopped the therapy. No other side-effect was observed. Oral UFT and CPA combination therapy was considered useful for metastatic breast cancer. To prevent leukopenia and prolong the term of treatment efficacy, a treatment regimen will need to be established.
AuthorsY Ogawa, T Ishikawa, K Ogisawa, K Ikeda, I Nagatsuka, Y Matsumura, T Takashima, M Yashiro, N Onoda, B Nakata, Y Kato, K Hirakawa
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 27 Issue 13 Pg. 2123-7 (Nov 2000) ISSN: 0385-0684 [Print] JAPAN
PMID11103246 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Tegafur
  • Uracil
  • Cyclophosphamide
  • Administration, Oral
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
  • Bone Neoplasms (secondary)
  • Breast Neoplasms (drug therapy, pathology)
  • Cyclophosphamide (administration & dosage)
  • Drug Administration Schedule
  • Drug Resistance, Neoplasm
  • Female
  • Humans
  • Lymphatic Metastasis
  • Middle Aged
  • Peritoneal Neoplasms (secondary)
  • Skin Neoplasms (secondary)
  • Tegafur (administration & dosage)
  • Uracil (administration & dosage)

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