Correlation between elevated intratumoral thymidine phosphorylase and prognosis of node-positive breast carcinoma undergoing adjuvant doxifluridine treatment.

Abstract	We determined intratumoral thymidine phosphorylase (dThdPase) activity in 213 patients with T2N0M0 or T2N1M0 breast cancer. After surgery doxifluridine, an intermediate metabolite of capecitabine, and tamoxifen were given by mouth. According to dThdPase activity the examined patients were classified as: A, high activity group; tumors with the activity not less than the mean value and B, low activity group; tumors with activity less than the mean value. Group A had a better prognosis than group B in node-positive patients (disease-free survival, p=0.0446; overall survival, p=0.0788). Intratumoral dThdPase activity might be a useful marker for predicting responsiveness to doxifluridine treatment in the adjuvant setting.
Authors	H Takahashi, Y Maeda, K Watanabe, K Taguchi, F Sasaki, S Todo
Journal	International journal of oncology (Int J Oncol) Vol. 17 Issue 6 Pg. 1205-11 (Dec 2000) ISSN: 1019-6439 [Print] Greece
PMID	11078806 (Publication Type: Journal Article)
Chemical References	Antimetabolites, Antineoplastic Enzyme Inhibitors Estrogens Neoplasm Proteins Receptors, Estrogen Receptors, Progesterone Floxuridine Progesterone Thymidine Phosphorylase doxifluridine
Topics	Adult Aged Antimetabolites, Antineoplastic (pharmacology, therapeutic use) Breast Neoplasms (drug therapy, enzymology, mortality, surgery) Carcinoma, Ductal, Breast (drug therapy, enzymology, mortality, surgery) Chemotherapy, Adjuvant Combined Modality Therapy Disease-Free Survival Enzyme Inhibitors (pharmacology, therapeutic use) Estrogens Female Floxuridine (pharmacology, therapeutic use) Genes, erbB-2 Humans Life Tables Lymphatic Metastasis Middle Aged Neoplasm Proteins (analysis, antagonists & inhibitors) Neoplasms, Hormone-Dependent (drug therapy, enzymology, mortality, surgery) Progesterone Prognosis Receptors, Estrogen (analysis) Receptors, Progesterone (analysis) Survival Analysis Thymidine Phosphorylase (analysis, antagonists & inhibitors)

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