Prognosis and clinicopathological characteristics of Ib-IIb adenocarcinoma of the uterine cervix in patients who have had radical hysterectomy.

Abstract

AIMS:

The aim of the present study was to evaluate the outcome of patients with stage lb-IIb cervical adenocarcinoma treated with radical hysterectomy, and to determine the clinicopathological characteristics of those patients.

METHODS:

A total of 255 patients with cervical carcinoma stage Ib-IIb (57 adenocarcinoma and 198 squamous cell carcinoma) who had undergone radical hysterectomy were included in this study. Patient survival distribution was calculated using the Kaplan-Meier method.

RESULTS:

The estimated 5-year survival rate for patients with adenocarcinoma was significantly poorer than that for patients with squamous cell carcinoma (77.9% vs 91.7%). The survival rate in stage Ib patients did not differ between two groups (95.8% vs 94.4% respectively). The incidence of lymph node involvement was significantly higher in patients with adenocarcinoma than in those with squamous cell carcinoma (31.6% vs 14.8%). Among patients receiving post-operative radiotherapy, the survival rate for adenocarcinoma (71.1%) was significantly poorer than that for squamous cell carcinoma (90.0%). When patients underwent radical hysterectomy, the survival rate for stage II patients with adenocarcinoma was significantly poorer than that for patients with squamous cell carcinoma.

CONCLUSIONS:

The higher incidence of lymph node involvement and lower response to post-operative radiotherapy are considered to be factors of poorer prognosis in cervical adenocarcinoma.

• Authors: T Irie, J Kigawa, Y Minagawa, H Itamochi, S Sato, R Akeshima, N Terakawa
• Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (Eur J Surg Oncol) Vol. 26 Issue 5 Pg. 464-7 (Aug 2000) ISSN: 0748-7983 [Print] England
• PMID: 11016467 (Publication Type: Journal Article)

Topics

• Adenocarcinoma (mortality, pathology, surgery)
• Adult
• Aged
• Carcinoma, Squamous Cell (mortality, pathology, surgery)
• Female
• Humans
• Hysterectomy (methods)
• Lymphatic Metastasis
• Medical Records
• Middle Aged
• Neoplasm Staging
• Prognosis
• Proportional Hazards Models
• Retrospective Studies
• Survival Analysis
• Uterine Cervical Neoplasms (mortality, pathology, surgery)