Abstract | BACKGROUND: OBJECTIVE: METHODS: RESULTS: Autologous graft-versus-host disease failed to develop in the any of the group A patients, who did not receive total body irradiation for conditioning and underwent the transplantation with unmanipulated peripheral blood stem cells, although cytotoxic activity against autologous lymphocytes was detectable in peripheral blood mononuclear cells obtained from all of them after the transplantation. Autologous graft-versus-host disease developed in 2 of 4 patients in group A who received enriched CD34(+) cells and in 7 of 11 patients who underwent conditioning with total body irradiation. Maculopapular erythema that was compatible with graft-versus-host disease developed on days 19 to 27 after the transplantation in these patients and resolved after 3 to 9 days without treatment. CONCLUSIONS:
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Authors | Y Miura, M Ueda, W Zeng, H Wang, A Takami, H Yamazaki, Y Kawamura, S Shiobara, S Nakao |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 106
Issue 1 Pt 2
Pg. S51-7
(Jul 2000)
ISSN: 0091-6749 [Print] United States |
PMID | 10887334
(Publication Type: Journal Article)
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Chemical References |
- Interferon-gamma
- Cyclosporine
|
Topics |
- Adult
- Cyclosporine
(therapeutic use)
- Cytotoxicity, Immunologic
- Female
- Graft vs Host Disease
(etiology)
- Hematopoietic Stem Cell Transplantation
(adverse effects)
- Humans
- Interferon-gamma
(therapeutic use, toxicity)
- Lymphocytes
(immunology)
- Lymphoma, Non-Hodgkin
(therapy)
- Male
- Middle Aged
- Transplantation Conditioning
- Transplantation, Autologous
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