Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria.

Abstract

The effects of phenytoin and its major metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This effect may be the cause of phenytoin-induced bone loss in vivo.

• Authors: A Takahashi, K Onodera, H Shinoda, H Mayanagi
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 82 Issue 1 Pg. 82-4 (Jan 2000) ISSN: 0021-5198 [Print] Japan
• PMID: 10874595 (Publication Type: Journal Article)

Chemical References

• hydroxyphenytoin
• Phenytoin

Topics

• Animals
• Bone Resorption (chemically induced)
• Mice
• Organ Culture Techniques
• Phenytoin (analogs & derivatives, metabolism, toxicity)
• Skull (drug effects)