New insights into the thyroid-stimulating hormone receptor. The major antigen of Graves' disease.

Abstract

The receptor for thyroid-stimulating hormone is one of the most interesting hormone-binding sites because of its close association with common human diseases, including thyroid nodules and Graves' hyperthyroidism. This article discusses the structure and biosynthetic processing of this elusive glycoprotein, whose paucity and instability have impeded its isolation from natural sources. Topics include cleavage and subunit structure, variant species, and structural modeling, the thyroid-stimulating hormone receptor as the major autoantigen in Graves' disease, and a summary of recent efforts to replicate the symptoms of this uniquely human disease in animal models.

• Authors: P N Graves, T F Davies
• Journal: Endocrinology and metabolism clinics of North America (Endocrinol Metab Clin North Am) Vol. 29 Issue 2 Pg. 267-86, vi (Jun 2000) ISSN: 0889-8529 [Print] United States
• PMID: 10874529 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)

Chemical References

• Autoantibodies
• Autoantigens
• Receptors, Thyrotropin
• Recombinant Proteins

Topics

• Alternative Splicing
• Amino Acid Sequence
• Animals
• Autoantibodies (immunology)
• Autoantigens (immunology)
• Disease Models, Animal
• Gene Expression
• Graves Disease (immunology)
• Humans
• Mice
• Models, Molecular
• Molecular Sequence Data
• Protein Structure, Secondary
• Receptors, Thyrotropin (chemistry, genetics, immunology, physiology)
• Recombinant Proteins