Downregulation of adenosine and P2X receptor-mediated cardiovascular responses in heart failure rats.

Abstract

Neurohormonal changes in congestive heart failure (CHF) include an enhanced peripheral sympathetic nerve activity which results in increased release of noradrenaline, neuropeptide Y and ATP. To examine if such changes in CHF would modulate peripheral pre- and postsynaptic receptors of ATP and its degradation product adenosine, experiments were performed in a rat model of ischaemic CHF. In this model, ischaemia was induced in rats by ligation of the left coronary artery. Our results demonstrate that there is a selective downregulation of P2X receptor-mediated pressor effects, while the hypotensive effects mediated by the endothelial P2Y receptors are unaffected in CHF. Moreover, the adenosine-mediated inhibitory effects on heart rate and blood pressure were also attenuated in the CHF rats. The most important changes in adenosine and P2-receptor function induced by ischaemic CHF were the reduced pressor effect mediated by the P2X receptor and the increased heart rate due to an attenuated inhibitory effect of adenosine.

• Authors: X H Zhao, X Y Sun, D Erlinge, L Edvinsson, T Hedner
• Journal: Blood pressure (Blood Press) Vol. 9 Issue 2-3 Pg. 152-61 ( 2000) ISSN: 0803-7051 [Print] England
• PMID: 10855740 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Purinergic P2 Receptor Agonists
• Receptors, Purinergic P2
• Adenosine Triphosphate
• Adenosine

Topics

• Adenosine (pharmacology, physiology)
• Adenosine Triphosphate (pharmacology)
• Animals
• Blood Pressure (drug effects)
• Cardiovascular System (physiopathology)
• Decerebrate State (physiopathology)
• Down-Regulation
• Electric Stimulation
• Ganglia (physiopathology)
• Heart Failure (complications, physiopathology)
• Heart Rate (drug effects)
• Male
• Myocardial Infarction (etiology, pathology)
• Purinergic P2 Receptor Agonists
• Rats
• Rats, Sprague-Dawley
• Receptors, Purinergic P2 (physiology)